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This page will hold a compendium of dosing recommendations for various medications.
Antibiotics:
Amikacin sulfate (Amiglyde-V®). Loading dose of 5 mg/kg IM and then 2.5 mg/kg every 72 hours for 5 treatments total. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Ceftazidime (Fortaz®). Human cephalosporin drug with good broad-spectrum activity, long half-life, kills Pseudomonas. Dose is 20 mg/kg IM or SC Q 72 hours. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Enrofloxacin (Baytril®). May be used IM, ICe and PO at a dose of 5-10 mg/kg/ Q 48 hours for 7-21 days. May be diluted with sterile saline since the concentrated form (2.27%) may be irritating. May also be used as a bath at a concentration of 2.5 mg/L for 5 hours Q 24 hours. Recent work (Lewbart et al., 2005) indicates 10 mg/kg ICe Q 5 days for koi at 20 degrees C. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Florfenicol. Based on salmonid literature, an estimated dose of 10-30 mg/kg administered IM every 24 hours would be required. This drug was recently (10/2005) approved for use in the U.S. in some food fish applications. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Trimethoprim sulfadiazine (Tribrissen®). A good broad-spectrum antibiotic. Dose is 30 mg/kg given IM, PO, or IC Q 24 hours for 7-10 days. May also be used as a bath at a concentration of 20 mg/L for 5 hours Q 24 hours. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Trimethoprim sulfamethoxazole (Bactrim, Septra, Aqua-sulfa) Potentiated sulfonamide is a bacterocidal antibiotic that inhibits protein synthesis. Broad spectrum antibiotic effective against both gram positive and gram negative bacteria (Most fish bacterial pathogens are gram negative), however, it may not be effective against pseudomonas (1). It is much preferable to plain sulfa antibiotics as the trimethroprim reduces bacterial resistance issues. The immersion dose is 20mg/L dosed daily with a 50% water change prior to each dose. Dose for 5-7 days. (As with most antibiotics, dosing in medicated food at 30mg/kg food is preferred. Source: Personal communication Dr. Helen Roberts).
Parasiticides:
Dimilin (Diflubenzuron) Dose is 0.01 mg/L for 48 hours, 3 treatments, 7 days apart. Very effective but may kill desirable environmental invertebrates. Anecdotal reports exist where veterinarians are prescribing lufenuron (Program®) at a similar dose with good success. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Panacur (Fenbendazole) A good parasiticide for intestinal nematodes. Can be given orally at a dose of 50-100 mg/kg and repeated in 2 weeks. Also can be used in a gel food at a concentration of 0.2% (200 mg/100 grams food) and fed for 3 days, repeated in 2 weeks. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Formalin Bath dose is 20-25mg/L for 12 to 24 hours followed by a 50% water change. 1.0 ml of 100% formalin (37% formaldehyde)/ 10 gallons (38 L) of water. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Bath: 0.125–0.25 mL/L bath every 24hours for 2–3 day for up to 60 minutes, or .015–0.025 mL/L (15-25ppm)
prolonged immersion, every 2–3 days. Change 50% water on nontreatment days. Is carcinogenic. (Source: Dr Helen Roberts, Veterinary Clinics: Exotic Animal Practice, Bacterial and Parasitic Diseases of Pet Fish)
Levamisole phosphate (Ripercol) 2 mg/L for 12-24 hours as a bath treatment. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Metronidazole (Flagy) Normally used as a bath treatment at 10 mg/L Q 24 hours for 3 consecutive days with 25-50% water changes between treatments. Also can be used in a gel food at a concentration of 0.2% (200 mg/100 grams food) and fed for 10 days. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Bath: 7–15 mg/L every 24-48 hours for 5–10 days with a 50% water change between treatments. Orally dose is 25–50 mg/kg (0.25% in food fed at 1% body weight per day) for 3 days. (Source: Dr Helen Roberts, Veterinary Clinics: Exotic Animal Practice, Bacterial and Parasitic Diseases of Pet Fish)
Praziquantel (Droncit) Dose is 5-8 mg/kg IM, IC, or PO repeated in 2 weeks. Bath treatment is 5-10 mg/L for 3-6 hours, repeat in 7 days. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Salt (sodium chloride) Safe for most species of ornamental fishes at a dose of 1 gram/L as an indefinite bath. Goldfish and koi will tolerate concentrations from 3-5 grams/L. (2 grams/L will usually kill circulating protozoal parasites. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Sedatives:
Clove Oil (Eugenol) Eugenol is not completely soluble in water and should be diluted 1:10 in 95% ethanol to yield a working stock solution of 100 mg/ml, since each ml of clove oil contains approximately 1 gram of drug. Concentrations of between 40 and 120 mg/L are effective in freshwater and marine species and results are comparable to MS-222, except that recovery may be prolonged. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Tricaine methanesulfonate (MS-222) Concentrations of between 100 and 150 mg/liter will usually anesthetize most fish within a matter of three to five minutes. (Source: Dr Greg Lewbart, 2008, Michigan Veterinary Conference Proceedings)
Diuretics:
Furosemide (Lasix) fish-0.5-2 mg/kg orally, IM, or IV (up to 8 mg/kg in emergencies.) (Source: University of Minnesota, Research Research Animal Resources, Veterinary Formulary)
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